To download actual word file click here
Virology - BIOS
534
Winter, 0000
Department of Biological Sciences
GENERAL INFORMATION
Instructor: Dr.
K. Essani, Professor
Office:
Wood Hall, Room 3931; Laboratory:
Haenicke Hall, Room 2007
Phone:
387-2661; Fax: 387-5609; Internet:
karim.essani@wmich.edu
Office Hours: Mondays
2:00-4:00 pm and Tuesdays 2:30-4:30 pm or by appointment
Prerequisite: BIOS
312, Biochemistry recommended
Time and Place: Tuesdays
and Thursdays, 6:00-7:20 pm
1728
Wood Hall
Credit Hours: 3.0
This
course is intended to introduce undergraduate and graduate students to recent
concepts in the biology and biochemistry of animal viruses. There is no
required text book. However, it is highly recommended that students make
extensive use of a number of virology texts and journals available in the
university library. There are also a number of web sites and data banks
accessible on the internet (see attached handout). The purpose of these
readings is to provide students with some conceptual background to help
comprehend lectures and readings. Most virology text books and web sites
contain a number of factual errors
and omissions. Emphasis should,
therefore, be placed on lectures and suggested readings. Lectures will cover
recent progress made in animal virology. A general knowledge of protein and
nucleic acid biochemistry, at least at the present high school level, will be
essential to understand lectures and suggested readings. Some basic questions in biochemistry may be included in any or all
exams.
Exams and Scoring: A
total of 100 points with five scoring opportunities as follows:
|
First Exam |
10 points |
|
Second Exam |
25 points |
|
Third Exam |
25 points |
|
Review Paper |
10 points |
|
Final Exam |
30 points [April 17,
' 01; 7:15 p.m.] |
The FINAL [COMPREHENSIVE] EXAM will be constructed as
follows: 10 points from lectures covered
in three previous exams [some questions may be from previous exams], and 20
points from lectures since third exam.
Any conflict in the final exam schedule must be resolved during first
two weeks of classes.
Total
numerical grade obtained by summing all scoring opportunities will translate
into letter grade as follows:
90-100 = A, 85-89 = BA, 79-84 = B, 72-78
= CB.
65-71 = C, 57-64 = DC, 50-56 = D, 0-49
= E.
Review Paper:
Every student will be required to write a
review article (not more than 20 double spaced typed pages) on a specific
animal virus. Each student will be assigned a different virus. Students are
required to use their own language. Not a single sentence should be plagiarized
from any other author. All facts must be referenced by number in the text and a
detailed bibliography must be included at the end of the review.
Each review must be subdivided into
following heads: classification, virion structure, virus genome including any
sequence data available (do not copy the nucleotide sequences, instead refer it
to the databank and access number), viral proteins (both structural and
non-structural and their functions), viral stability in environment (pH,
temperature and lipid solvents), replication cycle (including susceptible cell
lines and/or animals, cellular receptors and attachment protein(s), site of
virus replication within the cell, comprehensive biochemistry of virus
replication, assembly and release, and detailed clinical picture including the
description of disease in animals and/or humans, route of entry, pathogenesis,
diagnosis, treatment, vaccination and references. Figures and tables (maximum
two each) can be included in the review. These must be referenced, if not
original. Figures and tables must be incorporated in the text using any word
processing software. Do not use separate pages. Do not avoid any of these
subheadings. If information is not yet available, say so under that heading. The review will be due any time before the
3rd. exam, and may be submitted as early as possible for necessary comments and
corrections prior to final submission. Students are encouraged to read such
reviews in several scientific peer reviewed journals before writing their own.
First page must name the virus, student name, course title and number and
social security number.
Make-up Exams:
Any
make-up exam will be by special arrangements only, and will require written
documentation for an excused absence. Exams are to be made up immediately after
return to class and only approved excused absences are eligible for a make-up
exam. There will be no make-up review
papers.
Academic Honesty:
Academic
ethical standards regarding cheating, fabrication, plagiarism, facilitating
academic dishonesty and consequences of these actions are all described in the
WMU Undergraduate Catalog. Students sometimes do not understand the definitions
of academic standards (e.g. plagiarism) and unwittingly are party to improper
conduct. Thus it is important to familiarize yourself with this part of the
written definitions described above. Reading these regulations is strongly
recommended.
Lecture
# Topic
--------------------------------------------------------------------------------------------------------------------------------
1. Overview of Virology
2. Analytical
Technology in Virus Research
3. Structure
and Classification of Viruses
4. Viral
Replication
5. Viral
Genetics
6. Review and Discussion I
7. First Exam
8. Pathogenesis
and Immunology of Virus Infections
9. Laboratory
Diagnosis of Viral Infections
10. Persistent
Viral Infections
11. Tumor
Virology I
12. Tumor
Virology II
13. Review and Discussion II
14. Second Exam
15. Anti-Viral
Chemotherapy
16. Plus-
17. Plus-
18. Minus-
19. Double-Stranded
RNA Viruses
20. Review and Discussion III
21. Third Exam [ also Last Day for Review Submission]
22. Small
and Medium DNA Viruses
23. Large
DNA Viruses
24. Viruses,
Prions and Viroids
25. Virology
and Chemotherapy of AIDS
26. Review and Discussion IV
27. Final
Exam 7:15 p.m.
Any conflicts in the final exam must be resolved during the first two
weeks of classes.